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Advances in Cancer Research, Vol. 108 - download pdf or read online

By George F. Vande Woude (ed.), George Klein (ed.)

ISBN-10: 012380888X

ISBN-13: 9780123808882

Presents worthwhile info at the intriguing and fast-moving box of melanoma research. Outstanding and unique reports are offered on various themes.

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Deregulation of Cellular Pathways F. Single Nucleotide Polymorphism (SNP) Analysis G. Gender Disparity in HBV-Related HCC H. Identification of HCC Predisposition Gene(s) in Familial Multiplex HCC Advances in CANCER RESEARCH Copyright 2010, Elsevier Inc. All rights reserved. 1016/S0065-230X(10)08003-6 Jia-Horng Kao et al. 22 VII. Conclusions References Hepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, and more than half of HCC patients are attributable to persistent hepatitis B virus (HBV) infections.

2000b). , Table IV Reported Associations Between Core Promoter Mutations and Development of HBV-Related Hepatocellular Carcinoma Author (year) Study design Study population Yeh et al. (2000) Cross-sectional study 67 HCC; 100 chronic hepatitis B Kao et al. (2003) Cross-sectional study Liu et al. (2006a) Cross-sectional study 60 inactive carriers; 190 patients with different stages of liver disease 160 carriers; 200 HCC Tanaka et al. (2006) Matched cross-sectional control study 118 carriers with HBV/C1 (44% HCC) and 210 HBV/C2 (46% HCC) Muroyama et al.

Ample evidence documents that vaccination of newborns against HBV infection in Taiwan has effectively reduced persistent HBV infections from 15% in the pre-vaccination era to < 1% in the post-vaccination era (Kao and Chen, 2008). In addition, our recent population-based study in 46 Jia-Horng Kao et al. , 2009). The study included 1958 individuals aged 6–29 years diagnosed with HCC between July 1, 1983 and June 30, 2004. Of these, 508 were aged 6–19 years at diagnosis (444 unvaccinated, 64 vaccinated) and 1450 were aged 20–29 years at diagnosis (all unvaccinated).

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Advances in Cancer Research, Vol. 108 by George F. Vande Woude (ed.), George Klein (ed.)


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